MacroPermTM opens the possibility to deliver molecules that have previously been too large for effective transdermal delivery. While technology capable of permeating large molecules through the dermis and into the bloodstream by physical means exists, there is yet to be an elegant solution compatible with many types of large molecules—until now. 

MacroPermTM is designed to transport Active Pharmaceutical Ingredients (API), up to 25,000 dalton. The end result will be new transdermal patch drugs to help patients around the world. A patent protected proprietary drug delivery system, MacroPermTM makes possible the delivery of large molecules to address many challenging health issues.

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Biotts team members

Our Experience

MacroPermTM is the next evolution in Tapemark’s legacy of doing what has yet to be done by other transdermal CDMOs. Through our experience and expertise in transdermal drug delivery, we’ve opened new routes of drug delivery to meet an ever-growing demand for innovation in complex pharmaceutical systems. Large molecule transdermal drug delivery has the potential to deliver molecules at therapeutic levels that were previously not thought possible through patches. 

To bring MacroPermTM to market, we’ve partnered with Biotts, a Polish biotechnical company that develops proprietary drug delivery technologies. Biotts proprietary technology combined with Tapemark’s world-leading expertise in transdermal patch design, development, and manufacturing combine to create MacroPermTM


Up to 10x more bioavailability


Molecules to 25,000 Da


Potential of 5x less side effects

Creator of Innovative of Transdermal Technologies

HubSpot Video

About Large Molecule Drug Delivery

Traditional transdermal systems are limited by molecule size. At a certain molecule size, permeation stops due to the barrier of the dermis. While the vast majority of chemical and protein molecules have been incompatible with transdermal patch therapy, MacroPermTM now makes this type of delivery possible through a patch.

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What Our Partners Have to Say

"Tapemark has proven itself as a leader in development and manufacturing of pharmaceutical thin films. The team at Tapemark has been an invaluable partner in their expertise provided to support our technology transfers. They continue to be committed to the success of each of our projects."

Joe T – Senior Director, Technical Operations
Medium Size Branded Pharmaceutical Company

“We have partnered with Tapemark over the years for our transdermal patch projects. We have found Tapemark to be a great partner. Tapemark has become a one stop shop for transdermal product development and commercial manufacturing after expanding its capabilities.”

J.W. – Senior Director R&D
Medium Size Branded Pharmaceutical Company

“The Tapemark team met every technical challenge and applied the extra resources necessary for us to achieve a successful launch of one of our strategic products."

John B – VP External Operations
Large Generics Pharmaceutical Company

"We have partnered with Tapemark for several business-critical new product launches. We have found Tapemark to be flexible and customer-focused and willing to accommodate our changing needs to their best ability. It has been a pleasure working with the Tapemark team."

K.B. – VP Supply Chain
Global Generic Pharmaceutical Company

"We have partnered with Tapemark for our transdermal patch since 2013. We have found Tapemark to be a highly experienced and professional team. The most important aspect is however the collaboration between our companies in building a solid foundation for our partnership, mutual respect, and success in business."

K.R. – VP Commercial Ops
Small Specialty Branded Pharmaceutical Company

"We have been a supplier to Tapemark for over 7 years and in our experience, the people at Tapemark are a pleasure to work with. We have created a mutually beneficial business relationship by working through all aspects of the supply chain. Our mutual commitment to meet regularly helps us plan together and has been very beneficial to ensure that we meet all the requirements established by Tapemark. Working with a company like Tapemark is rewarding for us and we are honored to participate in your mission by playing a role to assist in the delivery of non-invasive products that aid in pain treatment."

D.C. – VP Sales and Marketing
Large Packaging Supplier

"Tapemark is a great customer and we have the utmost confidence to refer you."

D.C. – VP Sales
Technical Components Supplier
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